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- Title
M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo.
- Authors
Curry, Jennifer M; Eubank, Tim D; Roberts, Ryan D; Wang, Yijie; Pore, Nabendu; Maity, Amit; Marsh, Clay B
- Abstract
M-CSF recruits mononuclear phagocytes which regulate processes such as angiogenesis and metastases in tumors. VEGF is a potent activator of angiogenesis as it promotes endothelial cell proliferation and new blood vessel formation. Previously, we reported that in vitro M-CSF induces the expression of biologically-active VEGF from human monocytes.
- Publication
PloS one, 2008, Vol 3, Issue 10, pe3405
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003405