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- Title
Chemical addressability of ultraviolet-inactivated viral nanoparticles (VNPs).
- Authors
Rae, Chris; Koudelka, Kristopher J; Destito, Giuseppe; Estrada, Mayra N; Gonzalez, Maria J; Manchester, Marianne
- Abstract
Cowpea Mosaic Virus (CPMV) is increasingly being used as a nanoparticle platform for multivalent display of molecules via chemical bioconjugation to the capsid surface. A growing variety of applications have employed the CPMV multivalent display technology including nanoblock chemistry, in vivo imaging, and materials science. CPMV nanoparticles can be inexpensively produced from experimentally infected cowpea plants at high yields and are extremely stable. Although CPMV has not been shown to replicate in mammalian cells, uptake in mammalian cells does occur in vitro and in vivo. Thus, inactivation of the virus RNA genome is important for biosafety considerations, however the surface characteristics and chemical reactivity of the particles must be maintained in order to preserve chemical and structural functionality.
- Publication
PloS one, 2008, Vol 3, Issue 10, pe3315
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003315