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- Title
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.
- Authors
Tsigelny, Igor F; Crews, Leslie; Desplats, Paula; Shaked, Gideon M; Sharikov, Yuriy; Mizuno, Hideya; Spencer, Brian; Rockenstein, Edward; Trejo, Margarita; Platoshyn, Oleksandr; Yuan, Jason X-J; Masliah, Eliezer
- Abstract
Misfolding and pathological aggregation of neuronal proteins has been proposed to play a critical role in the pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) and Parkinson's disease (PD) are frequent neurodegenerative diseases of the aging population. While progressive accumulation of amyloid beta protein (Abeta) oligomers has been identified as one of the central toxic events in AD, accumulation of alpha-synuclein (alpha-syn) resulting in the formation of oligomers and protofibrils has been linked to PD and Lewy body Disease (LBD). We have recently shown that Abeta promotes alpha-syn aggregation and toxic conversion in vivo, suggesting that abnormal interactions between misfolded proteins might contribute to disease pathogenesis. However the molecular characteristics and consequences of these interactions are not completely clear.
- Publication
PloS one, 2008, Vol 3, Issue 9, pe3135
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003135