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- Title
Global self-organization of the cellular metabolic structure.
- Authors
De La Fuente, Ildefonso M; Martínez, Luis; Pérez-Samartín, Alberto L; Ormaetxea, Leire; Amezaga, Cristian; Vera-López, Antonio
- Abstract
Over many years, it has been assumed that enzymes work either in an isolated way, or organized in small catalytic groups. Several studies performed using "metabolic networks models" are helping to understand the degree of functional complexity that characterizes enzymatic dynamic systems. In a previous work, we used "dissipative metabolic networks" (DMNs) to show that enzymes can present a self-organized global functional structure, in which several sets of enzymes are always in an active state, whereas the rest of molecular catalytic sets exhibit dynamics of on-off changing states. We suggested that this kind of global metabolic dynamics might be a genuine and universal functional configuration of the cellular metabolic structure, common to all living cells. Later, a different group has shown experimentally that this kind of functional structure does, indeed, exist in several microorganisms.
- Publication
PloS one, 2008, Vol 3, Issue 8, pe3100
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003100