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- Title
Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders.
- Authors
Khalil, Asma; Muttukrishna, Shanthi; Harrington, Kevin; Jauniaux, Eric
- Abstract
Antihypertensive drugs are believed to lower blood pressure in pre-eclampsia by direct or central vasodilatory mechanisms. However, they could also act by decreasing production of anti-angiogenic proteins involved in the pathophysiology of hypertension and proteinuria in pre-eclampsia (PE). The aim of our study was to evaluate the impact of antihypertensive therapy with alpha methyldopa on maternal circulating levels and placental production of soluble fms-like tyrosine kinase 1 (sFlt-1), soluble endoglin (sEng), vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in hypertensive disorders of pregnancy.
- Publication
PloS one, 2008, Vol 3, Issue 7, pe2766
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0002766