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- Title
Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains.
- Authors
Faça, Vitor M; Ventura, Aviva P; Fitzgibbon, Mathew P; Pereira-Faça, Sandra R; Pitteri, Sharon J; Green, Ann E; Ireton, Renee C; Zhang, Qing; Wang, Hong; O'Briant, Kathy C; Drescher, Charles W; Schummer, Michèl; McIntosh, Martin W; Knudsen, Beatrice S; Hanash, Samir M
- Abstract
Elucidation of the repertoire of secreted and cell surface proteins of tumor cells is relevant to molecular diagnostics, tumor imaging and targeted therapies. We have characterized the cell surface proteome and the proteins released into the extra-cellular milieu of three ovarian cancer cell lines, CaOV3, OVCAR3 and ES2 and of ovarian tumor cells enriched from ascites fluid.
- Publication
PloS one, 2008, Vol 3, Issue 6, pe2425
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0002425