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- Title
Gremlin enhances the determined path to cardiomyogenesis.
- Authors
Kami, Daisuke; Shiojima, Ichiro; Makino, Hatsune; Matsumoto, Kenji; Takahashi, Yoriko; Ishii, Ryuga; Naito, Atsuhiko T; Toyoda, Masashi; Saito, Hirohisa; Watanabe, Masatoshi; Komuro, Issei; Umezawa, Akihiro
- Abstract
The critical event in heart formation is commitment of mesodermal cells to a cardiomyogenic fate, and cardiac fate determination is regulated by a series of cytokines. Bone morphogenetic proteins (BMPs) and fibroblast growth factors have been shown to be involved in this process, however additional factors needs to be identified for the fate determination, especially at the early stage of cardiomyogenic development.
- Publication
PloS one, 2008, Vol 3, Issue 6, pe2407
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0002407