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- Title
Adenosine transporter ENT4 is a direct target of EWS/WT1 translocation product and is highly expressed in desmoplastic small round cell tumor.
- Authors
Li, Hongjie; Smolen, Gromoslaw A; Beers, Lisa F; Xia, Li; Gerald, William; Wang, Joanne; Haber, Daniel A; Lee, Sean Bong
- Abstract
Desmoplastic Small Round Cell Tumor (DSRCT) is a highly aggressive malignancy that affects mainly adolescents and young adults. A defining characteristic of DSRCT is a specific chromosomal translocation, t(11;22)(p13;q12), that fuses EWS with WT1, leading to a production of two isoforms of chimeric transcription factor, EWS/WT1(-KTS) and EWS/WT1(+KTS). The chimeric proteins are thought to play critical roles in various stages of oncogenesis through aberrant transcription of different genes, but only a few of these genes have been identified.
- Publication
PloS one, 2008, Vol 3, Issue 6, pe2353
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0002353