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- Title
Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide.
- Authors
Morón, Belén; Bethune, Michael T; Comino, Isabel; Manyani, Hamid; Ferragud, Marina; López, Manuel Carlos; Cebolla, Angel; Khosla, Chaitan; Sousa, Carolina
- Abstract
Celiac disease is a permanent intolerance to gluten prolamins from wheat, barley, rye and, in some patients, oats. Partially digested gluten peptides produced in the digestive tract cause inflammation of the small intestine. High throughput, immune-based assays using monoclonal antibodies specific for these immunotoxic peptides would facilitate their detection in food and enable monitoring of their enzymatic detoxification. Two monoclonal antibodies, G12 and A1, were developed against a highly immunotoxic 33-mer peptide. The potential of each antibody for quantifying food toxicity for celiac patients was studied.
- Publication
PloS one, 2008, Vol 3, Issue 5, pe2294
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0002294