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- Title
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis.
- Authors
Königshoff, Melanie; Balsara, Nisha; Pfaff, Eva-Maria; Kramer, Monika; Chrobak, Izabella; Seeger, Werner; Eickelberg, Oliver
- Abstract
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function. Alveolar epithelial cell injury and hyperplasia, enhanced extracellular matrix deposition, and (myo)fibroblast activation are features of IPF. Wnt/beta-catenin signaling has been shown to determine epithelial cell fate during development. As aberrant reactivation of developmental signaling pathways has been suggested to contribute to IPF pathogenesis, we hypothesized that Wnt/beta-catenin signaling is activated in epithelial cells in IPF. Thus, we quantified and localized the expression and activity of the Wnt/beta-catenin pathway in IPF.
- Publication
PloS one, 2008, Vol 3, Issue 5, pe2142
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0002142