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- Title
Anti-inflammatory preconditioning by agonists of adenosine A1 receptor.
- Authors
Nakav, Sigal; Chaimovitz, Cidio; Sufaro, Yuval; Lewis, Eli C; Shaked, Gad; Czeiger, David; Zlotnik, Moshe; Douvdevani, Amos
- Abstract
Adenosine levels rise during inflammation and modulate inflammatory responses by engaging with four different G protein-coupled receptors. It is suggested that adenosine exhibits pro-inflammatory effects through its A(1) receptor (A(1)R), and anti-inflammatory effects through A(2A) receptor (A(2A)R). Therefore, understanding of the mechanisms that govern adenosine receptor regulation may advance treatment of various inflammatory disorders. We previously reported that peak A(1)R expression during leukocyte recruitment, is followed by a peak in A(2A)R during inflammation resolution.
- Publication
PloS one, 2008, Vol 3, Issue 5, pe2107
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0002107