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- Title
Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain.
- Authors
McGowan, Patrick O; Sasaki, Aya; Huang, Tony C T; Unterberger, Alexander; Suderman, Matthew; Ernst, Carl; Meaney, Michael J; Turecki, Gustavo; Szyf, Moshe
- Abstract
Alterations in gene expression in the suicide brain have been reported and for several genes DNA methylation as an epigenetic regulator is thought to play a role. rRNA genes, that encode ribosomal RNA, are the backbone of the protein synthesis machinery and levels of rRNA gene promoter methylation determine rRNA transcription.
- Publication
PloS one, 2008, Vol 3, Issue 5, pe2085
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0002085