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- Title
Functional significance of allelic variation at methuselah, an aging gene in Drosophila.
- Authors
Paaby, Annalise B; Schmidt, Paul S
- Abstract
Longevity and age-specific patterns of mortality are complex traits that vary within and among taxa. Multiple candidate genes for aging have been identified in model systems by extended longevity mutant phenotypes, including the G-protein coupled receptor methuselah (mth) in D. melanogaster. These genes offer important insights into the mechanisms of lifespan determination and have been major targets of interest in the biology of aging. However, it is largely unknown whether these genes contribute to genetic variance for lifespan in natural populations, and consequently contribute to lifespan evolution.
- Publication
PloS one, 2008, Vol 3, Issue 4, pe1987
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0001987