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- Title
Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke model.
- Authors
Daadi, Marcel M; Maag, Anne-Lise; Steinberg, Gary K
- Abstract
Human embryonic stem cells (hESCs) offer a virtually unlimited source of neural cells for structural repair in neurological disorders, such as stroke. Neural cells can be derived from hESCs either by direct enrichment, or by isolating specific growth factor-responsive and expandable populations of human neural stem cells (hNSCs). Studies have indicated that the direct enrichment method generates a heterogeneous population of cells that may contain residual undifferentiated stem cells that could lead to tumor formation in vivo.
- Publication
PloS one, 2008, Vol 3, Issue 2, pe1644
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0001644