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- Title
The in vivo transcriptome of Schistosoma mansoni in the prominent vector species Biomphalaria pfeifferi with supporting observations from Biomphalaria glabrata.
- Authors
Buddenborg, Sarah K; Kamel, Bishoy; Hanelt, Ben; Bu, Lijing; Zhang, Si-Ming; Mkoji, Gerald M; Loker, Eric S
- Abstract
The full scope of the genes expressed by schistosomes during intramolluscan development has yet to be characterized. Understanding the gene products deployed by larval schistosomes in their snail hosts will provide insights into their establishment, maintenance, asexual reproduction, ability to castrate their hosts, and their prolific production of human-infective cercariae. Using the Illumina platform, the intramolluscan transcriptome of Schistosoma mansoni was investigated in field-derived specimens of the prominent vector species Biomphalaria pfeifferi at 1 and 3 days post infection (d) and from snails shedding cercariae. These S. mansoni samples were derived from the same snails used in our complementary B. pfeifferi transcriptomic study. We supplemented this view with microarray analyses of S. mansoni from B. glabrata at 2d, 4d, 8d, 16d, and 32d to highlight robust features of S. mansoni transcription, even when a different technique and vector species was used.
- Publication
PLoS neglected tropical diseases, 2019, Vol 13, Issue 9, pe0007013
- ISSN
1935-2735
- Publication type
Journal Article
- DOI
10.1371/journal.pntd.0007013