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- Title
Cross-reactive Neutralizing Antibody Responses to Enterovirus 71 Infections in Young Children: Implications for Vaccine Development.
- Authors
Mei-Liang Huang; Pai-Shan Chiang; Min-Yuan Chia; Shu-Ting Luo; Luan-Yin Chang; Tzou-Yien Lin; Mei-Shang Ho; Min-Shi Lee
- Abstract
Background: Recently, enterovirus 71 (EV71) has caused life-threatening outbreaks involving neurological and cardiopulmonary complications in Asian children with unknown mechanism. EV71 has one single serotype but can be phylogenetically classified into 3 main genogroups (A, B and C) and 11 genotypes (A, B1,B5 and C1,C5). In Taiwan, nationwide EV71 epidemics with different predominant genotypes occurred in 1998 (C2), 2000-2001 (B4), 2004-2005 (C4), and 2008 (B5). In this study, sera were collected to measure cross-reactive neutralizing antibody titers against different genotypes. Methods: We collected historical sera from children who developed an EV71 infection in 1998, 2000, 2005, 2008, or 2010 and measured cross-reactive neutralizing antibody titers against all 11 EV71 genotypes. In addition, we aligned and compared the amino acid sequences of P1 proteins of the tested viruses. Results: Serology data showed that children infected with genogroups B and C consistently have lower neutralizing antibody titers against genogroup A (.4-fold difference). The sequence comparisons revealed that five amino acid signatures (N143D in VP2; K18R, H116Y, D167E, and S275A in VP1) are specific for genogroup A and may be related to the observed antigenic variations. Conclusions: This study documented antigenic variations among different EV71 genogroups and identified potential immunodominant amino acid positions. Enterovirus surveillance and vaccine development should monitor these positions.
- Publication
PLoS Neglected Tropical Diseases, 2013, Vol 7, Issue 2, p1
- ISSN
1935-2727
- Publication type
Academic Journal
- DOI
10.1371/journal.pntd.0002067