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- Title
Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response.
- Authors
Wege, Anja Kathrin; Florian, Christian; Ernst, Wolfgang; Zimara, Nicole; Schleicher, Ulrike; Hanses, Frank; Schmid, Maximilian; Ritter, Uwe
- Abstract
Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis. Unfortunately, chemotherapeutic interventions show high toxicity in addition to an increased risk of dissemination of drug-resistant parasites. An appropriate laboratory animal based model is still missing which allows testing of new drug strategies in the context of human immune cells in vivo.
- Publication
PLoS neglected tropical diseases, 2012, Vol 6, Issue 7, pe1741
- ISSN
1935-2735
- Publication type
Journal Article
- DOI
10.1371/journal.pntd.0001741