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- Title
Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.
- Authors
Moens, Britta; Decanine, Daniele; Menezes, Soraya Maria; Khouri, Ricardo; Silva-Santos, Gilvanéia; Lopez, Giovanni; Alvarez, Carolina; Talledo, Michael; Gotuzzo, Eduardo; de Almeida Kruschewsky, Ramon; Galvão-Castro, Bernardo; Vandamme, Anne-Mieke; Van Weyenbergh, Johan
- Abstract
Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) monotherapy in a large open clinical trial. However, there is a lack of in vivo and in vitro studies exploring and comparing the effects of high-dose AA and IFN-α treatment in the context of HAM/TSP. Therefore, we performed the first comparative analysis of the ex vivo and in vitro molecular and cellular mechanisms of action of IFN-α and high-dose AA in HAM/TSP.
- Publication
PLoS neglected tropical diseases, 2012, Vol 6, Issue 7, pe1729
- ISSN
1935-2735
- Publication type
Journal Article
- DOI
10.1371/journal.pntd.0001729