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- Title
Altered circulating levels of matrix metalloproteinases and inhibitors associated with elevated type 2 cytokines in lymphatic filarial disease.
- Authors
Anuradha, Rajamanickam; George, Jovvian P; Pavankumar, Nathella; Kumaraswami, Vasanthapuram; Nutman, Thomas B; Babu, Subash
- Abstract
Infection with Wuchereria bancrofti can cause severe disease characterized by subcutaneous fibrosis and extracellular matrix remodeling. Matrix metalloproteinases (MMPs) are a family of enzymes governing extracellular remodeling by regulating cellular homeostasis, inflammation, and tissue reorganization, while tissue-inhibitors of metalloproteinases (TIMPs) are endogenous regulators of MMPs. Homeostatic as well as inflammation-induced balance between MMPs and TIMPs is considered critical in mediating tissue pathology.
- Publication
PLoS neglected tropical diseases, 2012, Vol 6, Issue 6, pe1681
- ISSN
1935-2735
- Publication type
Journal Article
- DOI
10.1371/journal.pntd.0001681