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- Title
Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring.
- Authors
Sarfo, Fred S; Le Chevalier, Fabien; Aka, N'Guetta; Phillips, Richard O; Amoako, Yaw; Boneca, Ivo G; Lenormand, Pascal; Dosso, Mireille; Wansbrough-Jones, Mark; Veyron-Churlet, Romain; Guenin-Macé, Laure; Demangel, Caroline
- Abstract
Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU), is unique among human pathogens in its capacity to produce a polyketide-derived macrolide called mycolactone, making this molecule an attractive candidate target for diagnosis and disease monitoring. Whether mycolactone diffuses from ulcerated lesions in clinically accessible samples and is modulated by antibiotic therapy remained to be established.
- Publication
PLoS neglected tropical diseases, 2011, Vol 5, Issue 7, pe1237
- ISSN
1935-2735
- Publication type
Journal Article
- DOI
10.1371/journal.pntd.0001237