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- Title
Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica.
- Authors
Robinson, Mark W; Corvo, Ileana; Jones, Peter M; George, Anthony M; Padula, Matthew P; To, Joyce; Cancela, Martin; Rinaldi, Gabriel; Tort, Jose F; Roche, Leda; Dalton, John P
- Abstract
The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola hepatica in the host. Thus, infective larvae traversing the gut wall secrete cathepsin L3 (FhCL3), liver migrating juvenile parasites secrete both FhCL1 and FhCL2 while the mature bile duct parasites, which are obligate blood feeders, secrete predominantly FhCL1 but also FhCL2.
- Publication
PLoS neglected tropical diseases, 2011, Vol 5, Issue 4, pe1012
- ISSN
1935-2735
- Publication type
Journal Article
- DOI
10.1371/journal.pntd.0001012