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- Title
Geographical variation in the response of visceral leishmaniasis to paromomycin in East Africa: a multicentre, open-label, randomized trial.
- Authors
Hailu, Asrat; Musa, Ahmed; Wasunna, Monique; Balasegaram, Manica; Yifru, Sisay; Mengistu, Getahun; Hurissa, Zewdu; Hailu, Workagegnehu; Weldegebreal, Teklu; Tesfaye, Samson; Makonnen, Eyasu; Khalil, Eltahir; Ahmed, Osama; Fadlalla, Ahmed; El-Hassan, Ahmed; Raheem, Muzamil; Mueller, Marius; Koummuki, Yousif; Rashid, Juma; Mbui, Jane; Mucee, Geoffrey; Njoroge, Simon; Manduku, Veronica; Musibi, Alice; Mutuma, Geoffrey; Kirui, Fredrick; Lodenyo, Hudson; Mutea, Dedan; Kirigi, George; Edwards, Tansy; Smith, Peter; Muthami, Lawrence; Royce, Catherine; Ellis, Sally; Alobo, Moses; Omollo, Raymond; Kesusu, Josephine; Owiti, Rhoda; Kinuthia, John; Leishmaniasis East Africa Platform (LEAP) group
- Abstract
Visceral leishmaniasis (VL) is a major health problem in developing countries. The untreated disease is fatal, available treatment is expensive and often toxic, and drug resistance is increasing. Improved treatment options are needed. Paromomycin was shown to be an efficacious first-line treatment with low toxicity in India.
- Publication
PLoS neglected tropical diseases, 2010, Vol 4, Issue 10, pe709
- ISSN
1935-2735
- Publication type
Journal Article
- DOI
10.1371/journal.pntd.0000709