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- Title
Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.
- Authors
Kerr, Iain D; Wu, Peng; Marion-Tsukamaki, Rachael; Mackey, Zachary B; Brinen, Linda S
- Abstract
Trypanosoma brucei is the etiological agent of Human African Trypanosomiasis, an endemic parasitic disease of sub-Saharan Africa. TbCatB and rhodesain are the sole Clan CA papain-like cysteine proteases produced by the parasite during infection of the mammalian host and are implicated in the progression of disease. Of considerable interest is the exploration of these two enzymes as targets for cysteine protease inhibitors that are effective against T. brucei.
- Publication
PLoS neglected tropical diseases, 2010, Vol 4, Issue 6, pe701
- ISSN
1935-2735
- Publication type
Journal Article
- DOI
10.1371/journal.pntd.0000701