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- Title
Molecular evidence for a functional ecdysone signaling system in Brugia malayi.
- Authors
Tzertzinis, George; Egaña, Ana L; Palli, Subba Reddy; Robinson-Rechavi, Marc; Gissendanner, Chris R; Liu, Canhui; Unnasch, Thomas R; Maina, Claude V
- Abstract
Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. An understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervention. Pharmacological evidence suggests that ecdysteroids play a role in parasitic nematode molting and fertility although their specific function remains unknown. In insects, ecdysone triggers molting through the activation of the ecdysone receptor: a heterodimer of EcR (ecdysone receptor) and USP (Ultraspiracle).
- Publication
PLoS neglected tropical diseases, 2010, Vol 4, Issue 3, pe625
- ISSN
1935-2735
- Publication type
Journal Article
- DOI
10.1371/journal.pntd.0000625