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- Title
Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses.
- Authors
Fitzpatrick, Jennifer M; Peak, Emily; Perally, Samirah; Chalmers, Iain W; Barrett, John; Yoshino, Timothy P; Ivens, Alasdair C; Hoffmann, Karl F
- Abstract
Novel methods to identify anthelmintic drug and vaccine targets are urgently needed, especially for those parasite species currently being controlled by singular, often limited strategies. A clearer understanding of the transcriptional components underpinning helminth development will enable identification of exploitable molecules essential for successful parasite/host interactions. Towards this end, we present a combinatorial, bioinformatics-led approach, employing both statistical and network analyses of transcriptomic data, for identifying new immunoprophylactic and therapeutic lead targets to combat schistosomiasis.
- Publication
PLoS neglected tropical diseases, 2009, Vol 3, Issue 11, pe543
- ISSN
1935-2735
- Publication type
Journal Article
- DOI
10.1371/journal.pntd.0000543