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- Title
Optimal uses of antiretrovirals for prevention in HIV-1 serodiscordant heterosexual couples in South Africa: a modelling study.
- Authors
Hallett, Timothy B; Baeten, Jared M; Heffron, Renee; Barnabas, Ruanne; de Bruyn, Guy; Cremin, Íde; Delany, Sinead; Garnett, Geoffrey P; Gray, Glenda; Johnson, Leigh; McIntyre, James; Rees, Helen; Celum, Connie
- Abstract
Antiretrovirals have substantial promise for HIV-1 prevention, either as antiretroviral treatment (ART) for HIV-1-infected persons to reduce infectiousness, or as pre-exposure prophylaxis (PrEP) for HIV-1-uninfected persons to reduce the possibility of infection with HIV-1. HIV-1 serodiscordant couples in long-term partnerships (one member is infected and the other is uninfected) are a priority for prevention interventions. Earlier ART and PrEP might both reduce HIV-1 transmission in this group, but the merits and synergies of these different approaches have not been analyzed.
- Publication
PLoS medicine, 2011, Vol 8, Issue 11, pe1001123
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.1001123