We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effectiveness of early antiretroviral therapy initiation to improve survival among HIV-infected adults with tuberculosis: a retrospective cohort study.
- Authors
Franke, Molly F; Robins, James M; Mugabo, Jules; Kaigamba, Felix; Cain, Lauren E; Fleming, Julia G; Murray, Megan B
- Abstract
Randomized clinical trials examining the optimal time to initiate combination antiretroviral therapy (cART) in HIV-infected adults with sputum smear-positive tuberculosis (TB) disease have demonstrated improved survival among those who initiate cART earlier during TB treatment. Since these trials incorporated rigorous diagnostic criteria, it is unclear whether these results are generalizable to the vast majority of HIV-infected patients with TB, for whom standard diagnostic tools are unavailable. We aimed to examine whether early cART initiation improved survival among HIV-infected adults who were diagnosed with TB in a clinical setting.
- Publication
PLoS medicine, 2011, Vol 8, Issue 5, pe1001029
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.1001029