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- Title
Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial.
- Authors
de Silva, H Asita; Pathmeswaran, Arunasalam; Ranasinha, Channa D; Jayamanne, Shaluka; Samarakoon, Senarath B; Hittharage, Ariyasena; Kalupahana, Ranjith; Ratnatilaka, G Asoka; Uluwatthage, Wimalasiri; Aronson, Jeffrey K; Armitage, Jane M; Lalloo, David G; de Silva, H Janaka
- Abstract
Envenoming from snakebites is most effectively treated by antivenom. However, the antivenom available in South Asian countries commonly causes acute allergic reactions, anaphylactic reactions being particularly serious. We investigated whether adrenaline, promethazine, and hydrocortisone prevent such reactions in secondary referral hospitals in Sri Lanka by conducting a randomised, double-blind placebo-controlled trial.
- Publication
PLoS medicine, 2011, Vol 8, Issue 5, pe1000435
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.1000435