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- Title
HIV-1 drug resistance emergence among breastfeeding infants born to HIV-infected mothers during a single-arm trial of triple-antiretroviral prophylaxis for prevention of mother-to-child transmission: a secondary analysis.
- Authors
Zeh, Clement; Weidle, Paul J; Nafisa, Lillian; Lwamba, Humphrey M; Okonji, Jully; Anyango, Emily; Bondo, Philip; Masaba, Rose; Fowler, Mary Glenn; Nkengasong, John N; Thigpen, Michael C; Thomas, Timothy
- Abstract
Nevirapine and lamivudine given to mothers are transmitted to infants via breastfeeding in quantities sufficient to have biologic effects on the virus; this may lead to an increased risk of a breastfed infant's development of resistance to maternal antiretrovirals. The Kisumu Breastfeeding Study (KiBS), a single-arm open-label prevention of mother-to-child HIV transmission (PMTCT) trial, assessed the safety and efficacy of zidovudine, lamivudine, and either nevirapine or nelfinavir given to HIV-infected women from 34 wk gestation through 6 mo of breastfeeding. Here, we present findings from a KiBS trial secondary analysis that evaluated the emergence of maternal ARV-associated resistance among 32 HIV-infected breastfed infants.
- Publication
PLoS medicine, 2011, Vol 8, Issue 3, pe1000430
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.1000430