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- Title
Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies.
- Authors
Getahun, Haileyesus; Kittikraisak, Wanitchaya; Heilig, Charles M; Corbett, Elizabeth L; Ayles, Helen; Cain, Kevin P; Grant, Alison D; Churchyard, Gavin J; Kimerling, Michael; Shah, Sarita; Lawn, Stephen D; Wood, Robin; Maartens, Gary; Granich, Reuben; Date, Anand A; Varma, Jay K
- Abstract
The World Health Organization recommends the screening of all people living with HIV for tuberculosis (TB) disease, followed by TB treatment, or isoniazid preventive therapy (IPT) when TB is excluded. However, the difficulty of reliably excluding TB disease has severely limited TB screening and IPT uptake in resource-limited settings. We conducted an individual participant data meta-analysis of primary studies, aiming to identify a sensitive TB screening rule.
- Publication
PLoS medicine, 2011, Vol 8, Issue 1, pe1000391
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.1000391