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- Title
The APPLe study: a randomized, community-based, placebo-controlled trial of azithromycin for the prevention of preterm birth, with meta-analysis.
- Authors
van den Broek, Nynke R; White, Sarah A; Goodall, Mark; Ntonya, Chikondi; Kayira, Edith; Kafulafula, George; Neilson, James P
- Abstract
Premature birth is the major cause of perinatal mortality and morbidity in both high- and low-income countries. The causes of preterm labour are multiple but infection is important. We have previously described an unusually high incidence of preterm birth (20%) in an ultrasound-dated, rural, pregnant population in Southern Malawi with high burdens of infective morbidity. We have now studied the impact of routine prophylaxis with azithromycin as directly observed, single-dose therapy at two gestational windows to try to decrease the incidence of preterm birth.
- Publication
PLoS medicine, 2009, Vol 6, Issue 12, pe1000191
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.1000191