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- Title
Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.
- Authors
Pearce, Richard J; Pota, Hirva; Evehe, Marie-Solange B; Bâ, El-Hadj; Mombo-Ngoma, Ghyslain; Malisa, Allen L; Ord, Rosalynn; Inojosa, Walter; Matondo, Alexandre; Diallo, Diadier A; Mbacham, Wilfred; van den Broek, Ingrid V; Swarthout, Todd D; Getachew, Asefaw; Dejene, Seyoum; Grobusch, Martin P; Njie, Fanta; Dunyo, Samuel; Kweku, Margaret; Owusu-Agyei, Seth; Chandramohan, Daniel; Bonnet, Maryline; Guthmann, Jean-Paul; Clarke, Sian; Barnes, Karen I; Streat, Elizabeth; Katokele, Stark T; Uusiku, Petrina; Agboghoroma, Chris O; Elegba, Olufunmilayo Y; Cissé, Badara; A-Elbasit, Ishraga E; Giha, Hayder A; Kachur, S Patrick; Lynch, Caroline; Rwakimari, John B; Chanda, Pascalina; Hawela, Moonga; Sharp, Brian; Naidoo, Inbarani; Roper, Cally
- Abstract
Although the molecular basis of resistance to a number of common antimalarial drugs is well known, a geographic description of the emergence and dispersal of resistance mutations across Africa has not been attempted. To that end we have characterised the evolutionary origins of antifolate resistance mutations in the dihydropteroate synthase (dhps) gene and mapped their contemporary distribution.
- Publication
PLoS medicine, 2009, Vol 6, Issue 4, pe1000055
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.1000055