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- Title
Ovarian carcinoma subtypes are different diseases: implications for biomarker studies.
- Authors
Köbel, Martin; Kalloger, Steve E; Boyd, Niki; McKinney, Steven; Mehl, Erika; Palmer, Chana; Leung, Samuel; Bowen, Nathan J; Ionescu, Diana N; Rajput, Ashish; Prentice, Leah M; Miller, Dianne; Santos, Jennifer; Swenerton, Kenneth; Gilks, C Blake; Huntsman, David
- Abstract
Although it has long been appreciated that ovarian carcinoma subtypes (serous, clear cell, endometrioid, and mucinous) are associated with different natural histories, most ovarian carcinoma biomarker studies and current treatment protocols for women with this disease are not subtype specific. With the emergence of high-throughput molecular techniques, distinct pathogenetic pathways have been identified in these subtypes. We examined variation in biomarker expression rates between subtypes, and how this influences correlations between biomarker expression and stage at diagnosis or prognosis.
- Publication
PLoS medicine, 2008, Vol 5, Issue 12, pe232
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0050232