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- Title
Cancer screening: a mathematical model relating secreted blood biomarker levels to tumor sizes.
- Authors
Lutz, Amelie M; Willmann, Juergen K; Cochran, Frank V; Ray, Pritha; Gambhir, Sanjiv S
- Abstract
Increasing efforts and financial resources are being invested in early cancer detection research. Blood assays detecting tumor biomarkers promise noninvasive and financially reasonable screening for early cancer with high potential of positive impact on patients' survival and quality of life. For novel tumor biomarkers, the actual tumor detection limits are usually unknown and there have been no studies exploring the tumor burden detection limits of blood tumor biomarkers using mathematical models. Therefore, the purpose of this study was to develop a mathematical model relating blood biomarker levels to tumor burden.
- Publication
PLoS medicine, 2008, Vol 5, Issue 8, pe170
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0050170