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- Title
Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naïve populations and associate with reduced treatment efficacy.
- Authors
Johnson, Jeffrey A; Li, Jin-Fen; Wei, Xierong; Lipscomb, Jonathan; Irlbeck, David; Craig, Charles; Smith, Amanda; Bennett, Diane E; Monsour, Michael; Sandstrom, Paul; Lanier, E Randall; Heneine, Walid
- Abstract
Transmitted HIV-1 drug resistance can compromise initial antiretroviral therapy (ART); therefore, its detection is important for patient management. The absence of drug-associated selection pressure in treatment-naïve persons can cause drug-resistant viruses to decline to levels undetectable by conventional bulk sequencing (minority drug-resistant variants). We used sensitive and simple tests to investigate evidence of transmitted drug resistance in antiretroviral drug-naïve persons and assess the clinical implications of minority drug-resistant variants.
- Publication
PLoS medicine, 2008, Vol 5, Issue 7, pe158
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0050158