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- Title
Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration.
- Authors
Kirsch, Irving; Deacon, Brett J; Huedo-Medina, Tania B; Scoboria, Alan; Moore, Thomas J; Johnson, Blair T
- Abstract
Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance. Yet, the efficacy of the antidepressants may also depend on the severity of initial depression scores. The purpose of this analysis is to establish the relation of baseline severity and antidepressant efficacy using a relevant dataset of published and unpublished clinical trials.
- Publication
PLoS medicine, 2008, Vol 5, Issue 2, pe45
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0050045