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- Title
Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir.
- Authors
García-Lerma, J Gerardo; Otten, Ron A; Qari, Shoukat H; Jackson, Eddie; Cong, Mian-Er; Masciotra, Silvina; Luo, Wei; Kim, Caryn; Adams, Debra R; Monsour, Michael; Lipscomb, Jonathan; Johnson, Jeffrey A; Delinsky, David; Schinazi, Raymond F; Janssen, Robert; Folks, Thomas M; Heneine, Walid
- Abstract
In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pre-exposure prophylaxis (PrEP) with antiretroviral drugs could prove to be an effective intervention strategy if highly efficacious and cost-effective PrEP modalities are identified. We evaluated daily and intermittent PrEP regimens of increasing antiviral activity in a macaque model that closely resembles human transmission.
- Publication
PLoS medicine, 2008, Vol 5, Issue 2, pe28
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0050028