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- Title
Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting.
- Authors
Pietras, Kristian; Pahler, Jessica; Bergers, Gabriele; Hanahan, Douglas
- Abstract
Important support functions, including promotion of tumor growth, angiogenesis, and invasion, have been attributed to the different cell types populating the tumor stroma, i.e., endothelial cells, cancer-associated fibroblasts, pericytes, and infiltrating inflammatory cells. Fibroblasts have long been recognized inside carcinomas and are increasingly implicated as functional participants. The stroma is prominent in cervical carcinoma, and distinguishable from nonmalignant tissue, suggestive of altered (tumor-promoting) functions. We postulated that pharmacological targeting of putative stromal support functions, in particular those of cancer-associated fibroblasts, could have therapeutic utility, and sought to assess the possibility in a pre-clinical setting.
- Publication
PLoS medicine, 2008, Vol 5, Issue 1, pe19
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0050019