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- Title
In the era of systematic reviews, does the size of an individual trial still matter.
- Authors
Guyatt, Gordon H; Mills, Edward J; Elbourne, Diana
- Abstract
Systematic reviews that combine high-quality evidence from several trials are now widely considered to be at the top of the hierarchy of clinical evidence. Given the primacy of systematic reviews-and the fact that individual clinical trials rarely provide definitive answers to a clinical research question-some commentators question whether the sample size calculation for an individual trial still matters. Others point out that small trials can still be potentially misleading.
- Publication
PLoS medicine, 2008, Vol 5, Issue 1, pe4
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0050004