We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.
- Authors
Hughes, Anne E; Orr, Nick; Patterson, Chris; Esfandiary, Hossein; Hogg, Ruth; McConnell, Vivienne; Silvestri, Giuliana; Chakravarthy, Usha
- Abstract
Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. Those with the neovascular end-stage of disease have irreversible loss of central vision. AMD is a complex disorder in which genetic and environmental factors play a role. Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smoking also contributes to the etiology. We aimed to provide a model of disease risk based on these factors.
- Publication
PLoS medicine, 2007, Vol 4, Issue 12, pe355
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0040355