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- Title
Targeting of interferon-beta to produce a specific, multi-mechanistic oncolytic vaccinia virus.
- Authors
Kirn, David H; Wang, Yaohe; Le Boeuf, Fabrice; Bell, John; Thorne, Steve H
- Abstract
Oncolytic viruses hold much promise for clinical treatment of many cancers, but a lack of systemic delivery and insufficient tumor cell killing have limited their usefulness. We have previously demonstrated that vaccinia virus strains are capable of systemic delivery to tumors in mouse models, but infection of normal tissues remains an issue. We hypothesized that interferon-beta (IFN-beta) expression from an oncolytic vaccinia strain incapable of responding to this cytokine would have dual benefits as a cancer therapeutic: increased anticancer effects and enhanced virus inactivation in normal tissues. We report the construction and preclinical testing of this virus.
- Publication
PLoS medicine, 2007, Vol 4, Issue 12, pe353
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0040353