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- Title
Association of human herpesvirus-6B with mesial temporal lobe epilepsy.
- Authors
Fotheringham, Julie; Donati, Donatella; Akhyani, Nahid; Fogdell-Hahn, Anna; Vortmeyer, Alexander; Heiss, John D; Williams, Elizabeth; Weinstein, Steven; Bruce, Derek A; Gaillard, William D; Sato, Susumu; Theodore, William H; Jacobson, Steven
- Abstract
Human herpesvirus-6 (HHV-6) is a beta-herpesvirus with 90% seroprevalence that infects and establishes latency in the central nervous system. Two HHV-6 variants are known: HHV-6A and HHV-6B. Active infection or reactivation of HHV-6 in the brain is associated with neurological disorders, including epilepsy, encephalitis, and multiple sclerosis. In a preliminary study, we found HHV-6B DNA in resected brain tissue from patients with mesial temporal lobe epilepsy (MTLE) and have localized viral antigen to glial fibrillary acidic protein (GFAP)-positive glia in the same brain sections. We sought, first, to determine the extent of HHV-6 infection in brain material resected from MTLE and non-MTLE patients; and second, to establish in vitro primary astrocyte cultures from freshly resected brain material and determine expression of glutamate transporters.
- Publication
PLoS medicine, 2007, Vol 4, Issue 5, pe180
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0040180