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- Title
Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism.
- Authors
Pogue-Geile, Kay L; Chen, Ru; Bronner, Mary P; Crnogorac-Jurcevic, Tatjana; Moyes, Kara White; Dowen, Sally; Otey, Carol A; Crispin, David A; George, Ryan D; Whitcomb, David C; Brentnall, Teresa A
- Abstract
Pancreatic cancer is a deadly disease. Discovery of the mutated genes that cause the inherited form(s) of the disease may shed light on the mechanism(s) of oncogenesis. Previously we isolated a susceptibility locus for familial pancreatic cancer to chromosome location 4q32-34. In this study, our goal was to discover the identity of the familial pancreatic cancer gene on 4q32 and determine the function of that gene.
- Publication
PLoS medicine, 2006, Vol 3, Issue 12, pe516
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0030516