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- Title
Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus.
- Authors
Bauer, Jason W; Baechler, Emily C; Petri, Michelle; Batliwalla, Franak M; Crawford, Dianna; Ortmann, Ward A; Espe, Karl J; Li, Wentian; Patel, Dhavalkumar D; Gregersen, Peter K; Behrens, Timothy W
- Abstract
Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disorder that affects multiple organ systems and is characterized by unpredictable flares of disease. Recent evidence indicates a role for type I interferon (IFN) in SLE pathogenesis; however, the downstream effects of IFN pathway activation are not well understood. Here we test the hypothesis that type I IFN-regulated proteins are present in the serum of SLE patients and correlate with disease activity.
- Publication
PLoS medicine, 2006, Vol 3, Issue 12, pe491
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0030491