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- Title
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.
- Authors
Singh, Anju; Misra, Vikas; Thimmulappa, Rajesh K; Lee, Hannah; Ames, Stephen; Hoque, Mohammad O; Herman, James G; Baylin, Stephen B; Sidransky, David; Gabrielson, Edward; Brock, Malcolm V; Biswal, Shyam
- Abstract
Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-sensitive transcription factor that positively regulates the expression of genes encoding antioxidants, xenobiotic detoxification enzymes, and drug efflux pumps, and confers cytoprotection against oxidative stress and xenobiotics in normal cells. Kelch-like ECH-associated protein 1 (KEAP1) negatively regulates NRF2 activity by targeting it to proteasomal degradation. Increased expression of cellular antioxidants and xenobiotic detoxification enzymes has been implicated in resistance of tumor cells against chemotherapeutic drugs.
- Publication
PLoS medicine, 2006, Vol 3, Issue 10, pe420
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0030420