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- Title
Regulation of peripheral inflammation by spinal p38 MAP kinase in rats.
- Authors
Boyle, David L; Jones, Toni L; Hammaker, Deepa; Svensson, Camille I; Rosengren, Sanna; Albani, Salvatore; Sorkin, Linda; Firestein, Gary S
- Abstract
Somatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined. Previous studies suggest spinal cord p38 mitogen-activated protein (MAP) kinase and cytokines participate in nociceptive behavior. We therefore determined whether these pathways also regulate peripheral inflammation in rat adjuvant arthritis, which is a model of rheumatoid arthritis.
- Publication
PLoS medicine, 2006, Vol 3, Issue 9, pe338
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0030338