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- Title
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.
- Authors
Chi, Jen-Tsan; Wang, Zhen; Nuyten, Dimitry S A; Rodriguez, Edwin H; Schaner, Marci E; Salim, Ali; Wang, Yun; Kristensen, Gunnar B; Helland, Aslaug; Børresen-Dale, Anne-Lise; Giaccia, Amato; Longaker, Michael T; Hastie, Trevor; Yang, George P; van de Vijver, Marc J; Brown, Patrick O
- Abstract
Inadequate oxygen (hypoxia) triggers a multifaceted cellular response that has important roles in normal physiology and in many human diseases. A transcription factor, hypoxia-inducible factor (HIF), plays a central role in the hypoxia response; its activity is regulated by the oxygen-dependent degradation of the HIF-1alpha protein. Despite the ubiquity and importance of hypoxia responses, little is known about the variation in the global transcriptional response to hypoxia among different cell types or how this variation might relate to tissue- and cell-specific diseases.
- Publication
PLoS medicine, 2006, Vol 3, Issue 3, pe47
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0030047