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- Title
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.
- Authors
Barreiro, Luis B; Neyrolles, Olivier; Babb, Chantal L; Tailleux, Ludovic; Quach, Hélène; McElreavey, Ken; Helden, Paul D van; Hoal, Eileen G; Gicquel, Brigitte; Quintana-Murci, Lluis
- Abstract
Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis receptor on human dendritic cells. We reasoned that if DC-SIGN interacts with M. tuberculosis, as well as with other pathogens, variation in this gene might have a broad range of influence in the pathogenesis of a number of infectious diseases, including tuberculosis.
- Publication
PLoS medicine, 2006, Vol 3, Issue 2, pe20
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0030020