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- Title
An immune basis for malaria protection by the sickle cell trait.
- Authors
Williams, Thomas N; Mwangi, Tabitha W; Roberts, David J; Alexander, Neal D; Weatherall, David J; Wambua, Sammy; Kortok, Moses; Snow, Robert W; Marsh, Kevin
- Abstract
Malaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism of this resistance remains the subject of considerable debate. While it probably involves innate factors such as the reduced ability of Plasmodium falciparum parasites to grow and multiply in HbAS erythrocytes, recent observations suggest that it might also involve the accelerated acquisition of malaria-specific immunity.
- Publication
PLoS medicine, 2005, Vol 2, Issue 5, pe128
- ISSN
1549-1676
- Publication type
Journal Article
- DOI
10.1371/journal.pmed.0020128