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- Title
Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.
- Authors
Patsopoulos, Nikolaos A; Barcellos, Lisa F; Hintzen, Rogier Q; Schaefer, Catherine; van Duijn, Cornelia M; Noble, Janelle A; Raj, Towfique; Gourraud, Pierre-Antoine; Stranger, Barbara E; Oksenberg, Jorge; Olsson, Tomas; Taylor, Bruce V; Sawcer, Stephen; Hafler, David A; Carrington, Mary; De Jager, Philip L; de Bakker, Paul I W; IMSGC; ANZgene
- Abstract
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels of validation. Using SNP data from genome-wide studies, we imputed and tested classical alleles and amino acid polymorphisms in 8 classical human leukocyte antigen (HLA) genes in 5,091 cases and 9,595 controls. We identified 11 statistically independent effects overall: 6 HLA-DRB1 and one DPB1 alleles in class II, one HLA-A and two B alleles in class I, and one signal in a region spanning from MICB to LST1. This genomic segment does not contain any HLA class I or II genes and provides robust evidence for the involvement of a non-HLA risk allele within the MHC. Interestingly, this region contains the TNF gene, the cognate ligand of the well-validated TNFRSF1A MS susceptibility gene. The classical HLA effects can be explained to some extent by polymorphic amino acid positions in the peptide-binding grooves. This study dissects the independent effects in the MHC, a critical region for MS susceptibility that harbors multiple risk alleles.
- Publication
PLoS genetics, 2013, Vol 9, Issue 11, pe1003926
- ISSN
1553-7404
- Publication type
Journal Article
- DOI
10.1371/journal.pgen.1003926